Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17427 | Target Info | |||
| Target Name | Platelet glycoprotein Ib alpha (CD42b) | ||||
| Synonyms | Platelet glycoprotein Ib alpha chain; Glycoprotein Ibalpha; Glycocalicin; GPIbalpha; GPIbA; GPIb-alpha; GPIb alpha; GP-Ib alpha; Antigen CD42balpha; Antigen CD42b-alpha | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GP1BA | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Auxiliary transporters | [+] 2 Auxiliary transporters | + | |||
| Interacting Protein Name | 14-3-3 protein zeta/delta (YWHAZ) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Yeast two hybrid | [3] | |||
| Interacting Target Name | Filamin A (FLNA) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Non-muscle filamin; Nonmuscle filamin; FLN-A; FLN1; FLN; Filamin-A; Filamin-1; Filamin 1; Endothelial actin-binding protein; Endothelial actin cytoskeleton; Alpha-filamin; Actin-binding protein 280; ABP-280 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Co-localization | [5] | |||
| Peptidases | [+] 1 Peptidases | + | |||
| Interacting Protein Name | Coagulation factor XII (FA12) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Hageman factor; HAF; Coagulation factor XII | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-localization | [5] | |||
| 2 | Reconstituted Complex | [6] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Target Name | von Willebrand factor (VWF) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | vWF; F8VWF | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Co-crystal Structure | [7] | |||
| 2 | Far Western | [8] | |||
| 3 | Reconstituted Complex | [9] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha. J Biol Chem. 1996 Mar 29;271(13):7362-7. | ||||
| REF 2 | Role of 14-3-3 in platelet glycoprotein Ib-von Willebrand factor interaction-induced signaling. Int J Mol Sci. 2012;13(5):5364-74. | ||||
| REF 3 | Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta. Blood. 1998 Feb 15;91(4):1295-303. | ||||
| REF 4 | Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem. 2002 Jan 18;277(3):2151-9. | ||||
| REF 5 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 6 | Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J Biol Chem. 2000 Jul 28;275(30):22756-63. | ||||
| REF 7 | Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science. 2002 Aug 16;297(5584):1176-9. | ||||
| REF 8 | Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome. J Clin Invest. 1993 Sep;92(3):1213-20. | ||||
| REF 9 | Cross-linking of a monomeric 39/34-kDa dispase fragment of von Willebrand factor (Leu-480/Val-481-Gly-718) to the N-terminal region of the alpha-chain of membrane glycoprotein Ib on intact platelets with bis(sulfosuccinimidyl) suberate. Biochemistry. 1989 Oct 17;28(21):8326-36. | ||||
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