Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T19011 Target Info
Target Name M-phase inducer phosphatase 3 (MPIP3)
Synonyms Dual specificity phosphatase Cdc25C; Cdc25C phosphatase
Target Type Literature-reported Target
Gene Name CDC25C
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
MPIP3_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [6]
Isomerases [+] 1 Isomerases +
Interacting Target Name Rotamase Pin1 (PIN1) Clinical trial Target Interacting Protein Info
UniProt ID
PIN1_HUMAN 
Synonyms Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Protein-peptide [8]
Kinases [+] 4 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [9]
2 Protein-Fragment Complementation Assay [9]
3 Yeast two hybrid [10]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [11]
Interacting Target Name Microtubule affinity regulating kinase 3 (MARK3) Clinical trial Target Interacting Protein Info
UniProt ID
MARK3_HUMAN 
Synonyms Serine/threonine-protein kinase p78; Ser/Thr protein kinase PAR-1; Protein kinase STK10); Protein kinase STK10; Par-1a; MAP/microtubule affinity-regulating kinase 3; EMK-2; EMK2; ELKL motif kinase 2; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [12]
2 Reconstituted Complex [13]
Interacting Target Name Polo-like kinase 1 (PLK1) Clinical trial Target Interacting Protein Info
UniProt ID
PLK1_HUMAN 
Synonyms STPK13; Serine-threonine protein kinase 13; Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase 13; PLK-1; Plk1; PLK; Mitoticserine-threonine kinase polo-like kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [15]
Proteins 14-3-3 [+] 5 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [3]
5 Yeast two hybrid [16]
Interacting Target Name AS1 14-3-3 protein eta (YWHAH) Literature-reported Target Interacting Protein Info
UniProt ID
1433F_HUMAN 
Synonyms YWHA1; Protein AS1; 14-3-3 protein eta
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [3]
Interacting Protein Name 14-3-3 protein gamma (YWHAG) Interacting Protein Interacting Protein Info
UniProt ID
1433G_HUMAN 
Synonyms 14.3.3GAMMA; PPP1R170
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [3]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
Other proteins [+] 1 Other proteins +
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [17]
References  Top
REF 1 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 2 The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem. 2000 Feb 25;275(8):5600-5.
REF 3 Involvement of protein kinase PKN1 in G2/M delay caused by arsenite. Mol Carcinog. 2005 May;43(1):1-12.
REF 4 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 5 Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Cell Syst. 2017 Apr 26;4(4):430-444.e5.
REF 6 Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines. Oncogene. 2007 Nov 8;26(51):7185-93.
REF 7 The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 1;12(5):706-20.
REF 8 The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001 Nov;21(22):7617-28.
REF 9 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 10 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 11 An essential phosphorylation-site domain of human cdc25C interacts with both 14-3-3 and cyclins. J Biol Chem. 2000 Sep 15;275(37):28849-57.
REF 12 Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. J Cell Sci. 2006 Oct 1;119(Pt 19):4059-70.
REF 13 C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 1998 Mar;9(3):197-208.
REF 14 BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene. 2009 Aug 6;28(31):2806-20.
REF 15 The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal. 2000 Jun;12(6):405-11.
REF 16 Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12288-93.
REF 17 Cdc25C interacts with PCNA at G2/M transition. Oncogene. 2002 Mar 7;21(11):1717-26.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.