Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T32880 Target Info
Target Name HIF-prolyl hydroxylase 2 (HPH-2)
Synonyms SM-20; Prolyl hydroxylase domain-containing protein 2; PHD2; Hypoxia-inducible factor prolyl hydroxylase 2; HPH-2; HIF-PH2; Egl nine homolog 1; C1orf12
Target Type Patented-recorded Target
Gene Name EGLN1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
EGLN1_HUMAN 
Target Interacting Proteins  Top
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
Isomerases [+] 2 Isomerases +
Interacting Protein Name Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) Interacting Protein Interacting Protein Info
UniProt ID
FKBP8_HUMAN 
Synonyms FKBP38; FKBPr38
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [1]
4 Protein-peptide [4]
5 Yeast two hybrid [3]
6 Yeast two hybrid [5]
7 Yeast two hybrid [6]
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [1]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Biochemical Activity [11]
6 Co-crystal Structure [12]
7 Reconstituted Complex [13]
8 Yeast two hybrid [14]
Interacting Target Name Hypoxia-inducible factor 2 alpha (HIF-2A) Successful Target Interacting Protein Info
UniProt ID
EPAS1_HUMAN 
Synonyms PASD2; PAS domain-containing protein 2; MOP2; Member of PAS protein 2; Hypoxia-inducible factor 2-alpha; HLF; HIF-2-alpha; HIF2-alpha; HIF2A; HIF-1-alpha-like factor; EPAS-1; Endothelial PAS domain-containing protein 1; Class E basic helix-loop-helix protein 73; bHLHe73; Basic-helix-loop-helix-PAS protein MOP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [15]
2 Yeast two hybrid [5]
Other proteins [+] 2 Other proteins +
Interacting Target Name von Hippel-Lindau disease tumor suppressor (VHL) Patented-recorded Target Interacting Protein Info
UniProt ID
VHL_HUMAN 
Synonyms pVHL; Protein G7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Reconstituted Complex [17]
Interacting Protein Name Inhibitor of growth protein 4 (ING4) Interacting Protein Interacting Protein Info
UniProt ID
ING4_HUMAN 
Synonyms p29ING4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [19]
References  Top
REF 1 Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. J Biol Chem. 2013 Apr 5;288(14):9662-74.
REF 2 Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing. J Biol Chem. 2014 May 23;289(21):14656-65.
REF 3 The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
REF 4 Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem. 2009 Aug 21;284(34):23046-58.
REF 5 Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 2009 Jan 15;69(2):616-24.
REF 6 Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor. Chembiochem. 2016 Dec 14;17(24):2316-2323.
REF 7 SIRT2 regulates tumour hypoxia response by promoting HIF-1 hydroxylation. Oncogene. 2015 Mar 12;34(11):1354-62.
REF 8 pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 Aug 26;353(6302):929-32.
REF 9 Phospholipase D1 protein coordinates dynamic assembly of HIF-1-PHD-VHL to regulate HIF-1 stability. Oncotarget. 2014 Dec 15;5(23):11857-72.
REF 10 Phospholipase D2 promotes degradation of hypoxia-inducible factor-1 independent of lipase activity. Exp Mol Med. 2015 Nov 27;47:e196.
REF 11 Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger. Mol Pharmacol. 2005 Dec;68(6):1803-9.
REF 12 Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure. 2009 Jul 15;17(7):981-9.
REF 13 Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J Biol Chem. 2008 Feb 15;283(7):3808-15.
REF 14 Analysis of HIF-prolyl hydroxylases binding to substrates. Biochem Biophys Res Commun. 2006 Dec 15;351(2):313-20.
REF 15 Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline. J Biol Chem. 2009 Apr 3;284(14):9050-8.
REF 16 The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol. 2012 Jan 29;14(2):201-8.
REF 17 RHOBTB3 promotes proteasomal degradation of HIF through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 2015 Sep;25(9):1025-42.
REF 18 The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. Blood. 2007 Dec 15;110(13):4464-75.
REF 19 The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6.

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