| References |
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| REF 1 |
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway. J Biol Chem. 2013 Apr 5;288(14):9662-74.
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| REF 2 |
Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing. J Biol Chem. 2014 May 23;289(21):14656-65.
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| REF 3 |
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability. Mol Cell Biol. 2007 May;27(10):3758-68.
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| REF 4 |
Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38. J Biol Chem. 2009 Aug 21;284(34):23046-58.
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| REF 5 |
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response. Cancer Res. 2009 Jan 15;69(2):616-24.
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| REF 6 |
Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor. Chembiochem. 2016 Dec 14;17(24):2316-2323.
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| REF 7 |
SIRT2 regulates tumour hypoxia response by promoting HIF-1 hydroxylation. Oncogene. 2015 Mar 12;34(11):1354-62.
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| REF 8 |
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 Aug 26;353(6302):929-32.
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| REF 9 |
Phospholipase D1 protein coordinates dynamic assembly of HIF-1-PHD-VHL to regulate HIF-1 stability. Oncotarget. 2014 Dec 15;5(23):11857-72.
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| REF 10 |
Phospholipase D2 promotes degradation of hypoxia-inducible factor-1 independent of lipase activity. Exp Mol Med. 2015 Nov 27;47:e196.
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| REF 11 |
Inhibition of the catalytic activity of hypoxia-inducible factor-1alpha-prolyl-hydroxylase 2 by a MYND-type zinc finger. Mol Pharmacol. 2005 Dec;68(6):1803-9.
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| REF 12 |
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure. 2009 Jul 15;17(7):981-9.
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| REF 13 |
Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases. J Biol Chem. 2008 Feb 15;283(7):3808-15.
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| REF 14 |
Analysis of HIF-prolyl hydroxylases binding to substrates. Biochem Biophys Res Commun. 2006 Dec 15;351(2):313-20.
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| REF 15 |
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline. J Biol Chem. 2009 Apr 3;284(14):9050-8.
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| REF 16 |
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol. 2012 Jan 29;14(2):201-8.
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| REF 17 |
RHOBTB3 promotes proteasomal degradation of HIF through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 2015 Sep;25(9):1025-42.
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| REF 18 |
The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. Blood. 2007 Dec 15;110(13):4464-75.
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| REF 19 |
The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6.
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