Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T45758 Target Info
Target Name CD40L receptor (CD40)
Synonyms Tumor necrosis factor receptor superfamily member 5; TNFRSF5; CDw40; Bp50; B-cell surfaceantigen CD40; B-cell surface antigen CD40
Target Type Clinical trial Target
Gene Name CD40
Biochemical Class Cytokine receptor
UniProt ID
TNR5_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 4 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 3 (TRAF3) Interacting Protein Interacting Protein Info
UniProt ID
TRAF3_HUMAN 
Synonyms CAP.1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-crystal Structure [3]
4 Protein-peptide [4]
5 Reconstituted Complex [5]
6 Yeast two hybrid [2]
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Fluorescence Resonance Energy Transfer [7]
4 Reconstituted Complex [5]
5 Yeast two hybrid [8]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Fluorescence Resonance Energy Transfer [7]
4 Reconstituted Complex [5]
Interacting Target Name Cellular inhibitor of apoptosis 1 (BIRC2) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC2_HUMAN 
Synonyms TNFR2-TRAF-signaling complex protein 2; TNFR2TRAFsignaling complex protein 2; RNF48; RING-type E3 ubiquitin transferase BIRC2; RING finger protein 48; MIHB; Inhibitor of apoptosis protein 2; IAP2; IAP homolog B; hIAP-2; hIAP2; C-IAP1; CIAP1; Baculoviral IAP repeat-containing protein 2; Baculoviral IAP repeatcontaining protein 2; API1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
Adapter proteins [+] 2 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 5 (TRAF5) Interacting Protein Interacting Protein Info
UniProt ID
TRAF5_HUMAN 
Synonyms MGC:39780; RNF84
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Protein-peptide [4]
4 Reconstituted Complex [5]
Interacting Protein Name TNF receptor-associated factor 1 (TRAF1) Interacting Protein Interacting Protein Info
UniProt ID
TRAF1_HUMAN 
Synonyms EBI6; MGC:10353
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [1]
References  Top
REF 1 HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One. 2010 Jun 30;5(6):e11380.
REF 2 A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem. 1994 Dec 2;269(48):30069-72.
REF 3 Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10395-9.
REF 4 Comparison of the peptide binding preferences of three closely related TRAF paralogs: TRAF2, TRAF3, and TRAF5. Protein Sci. 2016 Jul;25(7):1273-89.
REF 5 Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1234-9.
REF 6 TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol. 2005 Nov;25(22):9806-19.
REF 7 Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes. Chin Med Sci J. 2010 Mar;25(1):1-12.
REF 8 MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature. 1997 Feb 6;385(6616):540-4.
REF 9 Molecular characterization of CD40 signaling intermediates. J Biol Chem. 2001 Nov 16;276(46):43334-42.

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