Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T49925 Target Info
Target Name Tyrosine-protein kinase Fgr (FGR)
Synonyms p58c-Fgr; p58-Fgr; p55-Fgr; SRC2; Proto-oncogene c-Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Target Type Literature-reported Target
Gene Name FGR
Biochemical Class Kinase
UniProt ID
FGR_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Protein-Fragment Complementation Assay [1]
3 Yeast two hybrid [2]
Interacting Target Name Tyrosine-protein kinase SYK (SYK) Successful Target Interacting Protein Info
UniProt ID
KSYK_HUMAN 
Synonyms Spleen tyrosine kinase; p72-Syk
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Yeast two hybrid [4]
Other proteins [+] 1 Other proteins +
Interacting Target Name Wiskott-Aldrich syndrome protein (WAS) Clinical trial Target Interacting Protein Info
UniProt ID
WASP_HUMAN 
Synonyms WASp; IMD2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Reconstituted Complex [5]
3 Reconstituted Complex [6]
References  Top
REF 1 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 2 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 3 Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct;15(4):507-19.
REF 4 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem. 2005 Jan 14;280(2):1543-51.
REF 5 Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases. Curr Biol. 1996 Aug 1;6(8):981-8.
REF 6 Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains. J Biol Chem. 1996 Oct 18;271(42):26291-5.

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