Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Tyrosine-protein kinase SYK (SYK) | Successful | Target Info | ||
| UniProt ID | KSYK_HUMAN | ||||
| Gene Name | SYK | ||||
| Gene ID | 6850 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Tyrosine-protein kinase SYK (SYK) | Target Info | PPI Info | [1] | |
| Interacting Patented-recorded Target(s) | Protein-tyrosine phosphatase SHP-1 (PTPN6) | Target Info | PPI Info | [2] | |
| Interacting Literature-reported Target(s) | E3 ubiquitin protein ligase CBLB (CBLB) | Target Info | PPI Info | [3] | |
| Signal transduction protein CBL (CBL) | Target Info | PPI Info | [4] | ||
| Tyrosine-protein kinase Fgr (FGR) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The microtubule-associated protein tau is phosphorylated by Syk. Biochim Biophys Acta. 2008 Feb;1783(2):188-92. | ||||
| REF 2 | Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem. 2000 Jun 9;275(23):17263-8. | ||||
| REF 3 | Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene. 1999 Feb 4;18(5):1147-56. | ||||
| REF 4 | Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323. J Biol Chem. 1998 Dec 25;273(52):35273-81. | ||||
| REF 5 | Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct;15(4):507-19. | ||||
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