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| Target General Information |
Top |
| Target ID |
T51426 |
Target Info
|
| Target Name |
Farnesoid X-activated receptor (FXR) |
| Synonyms |
Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; RIP14; Nuclear receptor subfamily 1 group H member 4; HRR1; Farnesol receptor HRR-1; FXR; Bile acid receptor; BAR |
| Target Type |
Successful Target |
| Gene Name |
NR1H4 |
| Biochemical Class |
Nuclear hormone receptor |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Nuclear hormone receptors |
[+] 1 Nuclear hormone receptors |
+ |
| Interacting Target Name |
Retinoic acid receptor RXR-alpha (RXRA) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[1] |
| 3 |
Yeast two hybrid |
[2] |
| References |
Top |
| REF 1 |
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 2009 Nov;10(5):392-404.
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| REF 2 |
Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85.
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