Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T60077 Target Info
Target Name Retinoic acid receptor RXR-beta (RXRB)
Synonyms Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2
Target Type Successful Target
Gene Name RXRB
Biochemical Class Nuclear hormone receptor
UniProt ID
RXRB_HUMAN 
Target Interacting Proteins  Top
Nuclear hormone receptors [+] 8 Nuclear hormone receptors +
Interacting Target Name Oxysterols receptor LXR-alpha (NR1H3) Patented-recorded Target Interacting Protein Info
UniProt ID
NR1H3_HUMAN 
Synonyms Nuclear receptor subfamily 1 group H member 3; Nuclear receptor LXRalpha; Nuclear orphan receptor LXR-alpha; LXRalpha; LXRA; Liver X receptor alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Yeast two hybrid [1]
2 Yeast two hybrid [2]
3 Yeast two hybrid [3]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [5]
Interacting Target Name Retinoic acid receptor gamma (RARG) Successful Target Interacting Protein Info
UniProt ID
RARG_HUMAN 
Synonyms RAR-gamma; Nuclear receptor subfamily 1 group B member 3; NR1B3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Yeast two hybrid [3]
Interacting Target Name Retinoic acid receptor alpha (RARA) Clinical trial Target Interacting Protein Info
UniProt ID
RARA_HUMAN 
Synonyms RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Yeast two hybrid [7]
Interacting Target Name Peroxisome proliferator-activated receptor delta (PPARD) Clinical trial Target Interacting Protein Info
UniProt ID
PPARD_HUMAN 
Synonyms PPAR-delta; PPARdelta; PPAR-beta; PPARB; Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Yeast two hybrid [3]
Interacting Target Name Oxysterols receptor LXR-beta (NR1H2) Clinical trial Target Interacting Protein Info
UniProt ID
NR1H2_HUMAN 
Synonyms UNR; Ubiquitously-expressed nuclear receptor; Nuclear receptor subfamily 1 group H member 2; Nuclear receptor NER; Nuclear orphan receptor LXR-beta; NER; LXRbeta; LXRB; Liver X receptor beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [8]
2 Yeast two hybrid [3]
Interacting Target Name Pregnane X receptor (NR1I2) Literature-reported Target Interacting Protein Info
UniProt ID
NR1I2_HUMAN 
Synonyms SXR; Steroid and xenobiotic receptor; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Yeast two hybrid [3]
Interacting Target Name Retinoic acid receptor beta (RARB) Successful Target Interacting Protein Info
UniProt ID
RARB_HUMAN 
Synonyms RAR-epsilon; RAR-beta; Nuclear receptor subfamily 1 group B member 2; NR1B2; HBV-activated protein; HAP
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [2]
References  Top
REF 1 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 2 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 3 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 4 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol. 2015 Jan 21;11(1):775.
REF 5 Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53.
REF 6 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 7 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 8 Identification of a novel DNA binding site for nuclear orphan receptor OR1. J Biol Chem. 1999 Apr 9;274(15):10421-9.
REF 9 Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol. 2013 Jun;83(6):1229-36.

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