Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63816 Target Info
Target Name Histone deacetylase 4 (HDAC4)
Synonyms KIAA0288; HD4
Target Type Clinical trial Target
Gene Name HDAC4
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID
HDAC4_HUMAN 
Target Interacting Proteins  Top
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-fractionation [4]
6 Reconstituted Complex [4]
7 Reconstituted Complex [5]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name PP2A subunit A isoform PR65-alpha (PPP2R1A) Interacting Protein Interacting Protein Info
UniProt ID
2AAA_HUMAN 
Synonyms PP2A.Aalpha; PP2AAALPHA; PR65A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
Kinases [+] 1 Kinases +
Interacting Protein Name Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) Interacting Protein Interacting Protein Info
UniProt ID
KCC2D_HUMAN 
Synonyms CAMKD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
4 Reconstituted Complex [8]
Nuclear hormone receptors [+] 3 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [10]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Reconstituted Complex [12]
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Reconstituted Complex [12]
Proteins 14-3-3 [+] 3 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [14]
3 Affinity Capture-Western [15]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [16]
6 Affinity Capture-Western [17]
7 Yeast two hybrid [18]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [14]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [19]
Interacting Protein Name 14-3-3 protein epsilon (YWHAE) Interacting Protein Interacting Protein Info
UniProt ID
1433E_HUMAN 
Synonyms 14.3.3E; HEL2; KCIP.1; MDCR; MDS
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [14]
3 Affinity Capture-Western [2]
Transcription regulators [+] 6 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [22]
4 Yeast two hybrid [23]
Interacting Protein Name Myocyte-specific enhancer factor 2D (MEF2D) Interacting Protein Interacting Protein Info
UniProt ID
MEF2D_HUMAN 
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [24]
3 Affinity Capture-Western [25]
4 Biochemical Activity [26]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [14]
3 Affinity Capture-Western [27]
4 Reconstituted Complex [4]
Interacting Protein Name Myocyte-specific enhancer factor 2C (MEF2C) Interacting Protein Interacting Protein Info
UniProt ID
MEF2C_HUMAN 
Synonyms C5DELq14.3; DEL5q14.3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Affinity Capture-Western [28]
3 Yeast two hybrid [18]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [27]
3 Reconstituted Complex [4]
Interacting Protein Name Zinc finger and BTB domain-containing protein 16 (ZBTB16) Interacting Protein Interacting Protein Info
UniProt ID
ZBT16_HUMAN 
Synonyms PLZF; ZNF145
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Affinity Capture-Western [30]
3 Reconstituted Complex [31]
Other proteins [+] 3 Other proteins +
Interacting Protein Name Ankyrin repeat family A protein 2 (ANKRA2) Interacting Protein Interacting Protein Info
UniProt ID
ANRA2_HUMAN 
Synonyms ANKRA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Reconstituted Complex [18]
3 Yeast two hybrid [18]
4 Yeast two hybrid [33]
Interacting Target Name Nucleus accumbens-associated protein 1 (NACC1) Literature-reported Target Interacting Protein Info
UniProt ID
NACC1_HUMAN 
Synonyms NAC-1; NAC1; BTBD14B; BTB/POZ domain-containing protein 14B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Reconstituted Complex [34]
3 Reconstituted Complex [35]
Interacting Protein Name Splicing factor 1 (SF1) Interacting Protein Interacting Protein Info
UniProt ID
SF01_HUMAN 
Synonyms BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [36]
References  Top
REF 1 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 2 Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7835-40.
REF 3 Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):4868-73.
REF 4 Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002 Jan;9(1):45-57.
REF 5 Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. J Biol Chem. 2001 Sep 21;276(38):35826-35.
REF 6 Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med. 2012 May;18(5):783-90.
REF 7 Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells. J Biol Chem. 2007 Mar 9;282(10):7219-31.
REF 8 CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest. 2006 Jul;116(7):1853-64.
REF 9 Recruitment of histone deacetylase 4 to the N-terminal region of estrogen receptor alpha. Mol Endocrinol. 2005 Dec;19(12):2930-42.
REF 10 Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor. Circ Res. 2010 Jan 8;106(1):155-65.
REF 11 Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation. Oncogene. 2011 May 12;30(19):2207-18.
REF 12 Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):1-12.
REF 13 Peroxisome proliferator-activated receptor is inhibited by histone deacetylase 4 in cortical neurons under oxidative stress. J Neurochem. 2011 Aug;118(3):429-39.
REF 14 The functional interactome landscape of the human histone deacetylase family. Mol Syst Biol. 2013;9:672.
REF 15 The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 2001 Sep 14;276(37):35042-8.
REF 16 p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet. 2007 Jul 1;16(13):1541-56.
REF 17 The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases. J Biol Chem. 2013 Mar 29;288(13):9345-62.
REF 18 Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. J Biol Chem. 2005 Aug 12;280(32):29117-27.
REF 19 Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Mol Cell Biol. 2000 Sep;20(18):6904-12.
REF 20 Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Res. 2006 Sep 1;66(17):8814-21.
REF 21 Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases. Cancer Res. 2011 Feb 1;71(3):1187-95.
REF 22 Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1. FEBS Lett. 2009 Jan 5;583(1):55-60.
REF 23 Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity. J Biol Chem. 2004 Oct 1;279(40):41966-74.
REF 24 HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. Mol Cell Biol. 1999 Nov;19(11):7816-27.
REF 25 Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation. J Biol Chem. 2006 Feb 17;281(7):4423-33.
REF 26 Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005 Oct;25(19):8456-64.
REF 27 Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev. 2000 Jan 1;14(1):45-54.
REF 28 Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol Cell Biol. 2008 May;28(10):3437-45.
REF 29 HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene. 2004 Nov 18;23(54):8777-84.
REF 30 Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene. 2009 Oct 15;28(41):3663-70.
REF 31 Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem. 2002 Jun 14;277(24):22045-52.
REF 32 Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8. Structure. 2015 Apr 7;23(4):700-12.
REF 33 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 34 The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures. J Neurochem. 2005 Aug;94(3):786-93.
REF 35 Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1 axis. Oncogene. 2017 Jul 20;36(29):4171-4181.
REF 36 Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B. Mol Cell Biol. 2003 Sep;23(17):6000-12.

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