Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T64022 Target Info
Target Name Importin beta (KPNB1)
Synonyms Pore targeting complex 97 kDa subunit; PTAC97; Nuclear factor p97; NTF97; Karyopherin subunit beta1; Karyopherin subunit beta-1; Importin90; Importin-90; Importin subunit beta1; Importin subunit beta-1
Target Type Literature-reported Target
Gene Name KPNB1
Biochemical Class Eukaryotic nuclear pore complex
UniProt ID
IMB1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 SUMO-protein ligase RanBP2 (RANBP2) Interacting Protein Interacting Protein Info
UniProt ID
RBP2_HUMAN 
Synonyms ADANE; ANE1; IIAE3; NUP358; TRP1; TRP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-fractionation [2]
4 Reconstituted Complex [3]
Hydrolysis-driven transporters [+] 1 Hydrolysis-driven transporters +
Interacting Protein Name Nuclear RNA export factor 1 (NXF1) Interacting Protein Interacting Protein Info
UniProt ID
NXF1_HUMAN 
Synonyms MEX67; TAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [5]
Membrane-bounded channels [+] 8 Membrane-bounded channels +
Interacting Protein Name Nuclear pore complex protein Nup153 (NUP153) Interacting Protein Interacting Protein Info
UniProt ID
NU153_HUMAN 
Synonyms HNUP153; N153
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Reconstituted Complex [7]
4 Reconstituted Complex [8]
5 Reconstituted Complex [3]
Interacting Protein Name Importin subunit alpha-1 (KPNA2) Interacting Protein Interacting Protein Info
UniProt ID
IMA1_HUMAN 
Synonyms IPOA1; QIP2; RCH1; SRP1alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [9]
Interacting Protein Name Importin subunit alpha-3 (KPNA4) Interacting Protein Interacting Protein Info
UniProt ID
IMA3_HUMAN 
Synonyms IPOA3; QIP1; SRP3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [10]
Interacting Protein Name Importin subunit alpha-5 (KPNA1) Interacting Protein Interacting Protein Info
UniProt ID
IMA5_HUMAN 
Synonyms IPOA5; NPI.1; RCH2; SRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [11]
Interacting Protein Name Importin-7 (IPO7) Interacting Protein Interacting Protein Info
UniProt ID
IPO7_HUMAN 
Synonyms Imp7; RANBP7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [12]
Interacting Protein Name Importin-8 (IPO8) Interacting Protein Interacting Protein Info
UniProt ID
IPO8_HUMAN 
Synonyms RANBP8
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-fractionation [13]
2 Reconstituted Complex [12]
Interacting Protein Name Nuclear pore complex protein Nup50 (NUP50) Interacting Protein Interacting Protein Info
UniProt ID
NUP50_HUMAN 
Synonyms NPAP60; NPAP60L
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [14]
Interacting Protein Name mRNA export factor (RAE1) Interacting Protein Interacting Protein Info
UniProt ID
RAE1L_HUMAN 
Synonyms MIG14; MRNP41; Mnrp41; dJ481F12.3; dJ800J21.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [15]
Nuclear RNA exporters [+] 1 Nuclear RNA exporters +
Interacting Protein Name GTP-binding nuclear protein Ran (RAN) Interacting Protein Interacting Protein Info
UniProt ID
RAN_HUMAN 
Synonyms ARA24; Gsp1; TC4
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [2]
4 Co-fractionation [2]
5 Co-fractionation [13]
6 Co-fractionation [16]
7 Far Western [17]
8 Reconstituted Complex [11]
9 Reconstituted Complex [12]
10 Reconstituted Complex [18]
11 Reconstituted Complex [19]
12 Reconstituted Complex [20]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Nuclear pore complex protein Nup98-Nup96 (NUP98) Interacting Protein Interacting Protein Info
UniProt ID
NUP98_HUMAN 
Synonyms ADIR2; NUP196; NUP96
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [13]
3 Reconstituted Complex [21]
4 Reconstituted Complex [22]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name Telomeric repeat-binding factor 1 (TERF1) Literature-reported Target Interacting Protein Info
UniProt ID
TERF1_HUMAN 
Synonyms TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; Telomeric protein Pin2/TRF1; PIN2; NIMA-interacting protein 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [23]
2 Reconstituted Complex [24]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Ran-specific GTPase-activating protein (RANBP1) Interacting Protein Interacting Protein Info
UniProt ID
RANG_HUMAN 
Synonyms HTF9A
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [2]
4 Co-fractionation [2]
5 Reconstituted Complex [18]
6 Reconstituted Complex [19]
7 Reconstituted Complex [20]
Interacting Protein Name Regulator of chromosome condensation (RCC1) Interacting Protein Interacting Protein Info
UniProt ID
RCC1_HUMAN 
Synonyms CHC1; RCC1.I; SNHG3.RCC1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [25]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import. J Cell Biol. 1996 Nov;135(3):559-69.
REF 3 Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. J Cell Biol. 2001 Jan 22;152(2):411-7.
REF 4 Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1. Mol Biol Cell. 2011 Dec;22(23):4657-68.
REF 5 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58.
REF 6 Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells. Chromosoma. 2010 Dec;119(6):651-68.
REF 7 Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J. 1999 Apr 1;18(7):1982-95.
REF 8 Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. J Biol Chem. 2000 Jun 9;275(23):17848-56.
REF 9 Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta. Mol Cell Biol. 2001 Apr;21(8):2779-89.
REF 10 Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport. Cancer Res. 2016 Apr 15;76(8):2443-52.
REF 11 Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. J Mol Biol. 1997 Mar 7;266(4):722-32.
REF 12 A novel class of RanGTP binding proteins. J Cell Biol. 1997 Jul 14;138(1):65-80.
REF 13 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 14 Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import. Cell. 2002 Aug 9;110(3):349-60.
REF 15 A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell. 2005 Apr 22;121(2):223-34.
REF 16 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 17 Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J. 1997 Mar 17;16(6):1153-63.
REF 18 Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Mol Cell Biol. 2000 May;20(10):3510-21.
REF 19 A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells. J Cell Biol. 1999 Feb 22;144(4):645-55.
REF 20 Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97. J Biol Chem. 1997 Mar 7;272(10):6818-22.
REF 21 Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5055-60.
REF 22 Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity. Elife. 2015 Jan 6;4.
REF 23 The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One. 2010 Aug 25;5(8):e12407.
REF 24 Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha. Biochemistry. 2002 Jul 30;41(30):9333-40.
REF 25 RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation. J Cell Sci. 2007 Oct 1;120(Pt 19):3436-45.

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