Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | Telomeric repeat-binding factor 1 (TERF1) | Literature-reported | Target Info | ||
| UniProt ID | TERF1_HUMAN | ||||
| Gene Name | TERF1 | ||||
| Gene ID | 7013 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Clinical trial Target(s) | ATM serine/threonine kinase (ATM) | Target Info | PPI Info | [1] | |
| Tankyrase-1 (TNKS-1) | Target Info | PPI Info | [2] | ||
| Tankyrase-2 (TNKS-2) | Target Info | PPI Info | [3] | ||
| Interacting Literature-reported Target(s) | Importin beta (KPNB1) | Target Info | PPI Info | [4] | |
| Telomeric repeat-binding factor 1 (TERF1) | Target Info | PPI Info | [4] | ||
| PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) | Target Info | PPI Info | [5] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem. 2001 Aug 3;276(31):29282-91. | ||||
| REF 2 | Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol. 2002 Jan;22(1):332-42. | ||||
| REF 3 | Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem. 2000 Dec 8;275(49):38437-44. | ||||
| REF 4 | The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One. 2010 Aug 25;5(8):e12407. | ||||
| REF 5 | The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 2001 Nov 2;107(3):347-59. | ||||
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