Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T80042 Target Info
Target Name Telomeric repeat-binding factor 1 (TERF1)
Synonyms Telomeric protein Pin2/TRF1; TTAGGG repeat-binding factor 1; TRF1; TRF; TRBF1; PIN2; NIMA-interacting protein 2
Target Type Literature-reported Target
Gene Name TERF1
UniProt ID
TERF1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [2]
Glycosyltransferases [+] 2 Glycosyltransferases +
Interacting Target Name Tankyrase-1 (TNKS-1) Clinical trial Target Interacting Protein Info
UniProt ID
TNKS1_HUMAN 
Synonyms TRF1-interacting ankyrin-related ADP-ribose polymerase; TNKS1; TINF1; TIN1; Tankyrase I; TANK1; Protein poly-ADP-ribosyltransferase tankyrase-1; Poly [ADP-ribose] polymerase tankyrase-1; Poly [ADP-ribose] polymerase 5A; PARPL; PARP5A; ARTD5; ADP-ribosyltransferase diphtheria toxin-like 5
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [5]
5 Affinity Capture-MS [6]
6 Affinity Capture-Western [7]
7 Affinity Capture-Western [8]
8 Biochemical Activity [9]
9 Co-purification [8]
10 Reconstituted Complex [10]
11 Reconstituted Complex [11]
12 Reconstituted Complex [12]
13 Yeast two hybrid [9]
14 Yeast two hybrid [13]
Interacting Target Name Tankyrase-2 (TNKS-2) Clinical trial Target Interacting Protein Info
UniProt ID
TNKS2_HUMAN 
Synonyms TRF1-interacting ankyrin-related ADP-ribose polymerase 2; TNKL; Tankyrase-related protein; Tankyrase-like protein; Tankyrase II; TANK2; Protein poly-ADP-ribosyltransferase tankyrase-2; Poly [ADP-ribose] polymerase tankyrase-2; Poly [ADP-ribose] polymerase 5B; PARP5B; ARTD6; ADP-ribosyltransferase diphtheria toxin-like 6
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Reconstituted Complex [14]
4 Reconstituted Complex [11]
5 Reconstituted Complex [15]
Kinases [+] 1 Kinases +
Interacting Target Name ATM serine/threonine kinase (ATM) Clinical trial Target Interacting Protein Info
UniProt ID
ATM_HUMAN 
Synonyms Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [16]
3 Reconstituted Complex [17]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Target Name Importin beta (KPNB1) Literature-reported Target Interacting Protein Info
UniProt ID
IMB1_HUMAN 
Synonyms PTAC97; Pore targeting complex 97 kDa subunit; Nuclear factor p97; NTF97; Karyopherin subunit beta-1; Karyopherin subunit beta1; Importin-90; Importin90; Importin subunit beta-1; Importin subunit beta1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [18]
Other proteins [+] 5 Other proteins +
Interacting Protein Name TERF1-interacting nuclear factor 2 (TINF2) Interacting Protein Interacting Protein Info
UniProt ID
TINF2_HUMAN 
Synonyms DKCA3; TIN2
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [19]
5 Affinity Capture-Western [8]
6 Far Western [20]
7 Reconstituted Complex [19]
8 Yeast two hybrid [21]
9 Yeast two hybrid [22]
10 Yeast two hybrid [2]
Interacting Protein Name F-box only protein 4 (FBXO4) Interacting Protein Interacting Protein Info
UniProt ID
FBX4_HUMAN 
Synonyms FBX4
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Affinity Capture-Western [19]
3 Affinity Capture-Western [24]
4 Affinity Capture-Western [25]
5 Reconstituted Complex [23]
6 Reconstituted Complex [26]
7 Reconstituted Complex [27]
Interacting Target Name PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) Literature-reported Target Interacting Protein Info
UniProt ID
PINX1_HUMAN 
Synonyms TRF1-interacting protein 1; Protein 67-11-3; Pin2-interacting protein X1; LPTS; LPTL; Liver-related putative tumor suppressor
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [28]
3 Reconstituted Complex [29]
4 Yeast two hybrid [2]
5 Yeast two hybrid [30]
Interacting Protein Name Protection of telomeres protein 1 (POT1) Interacting Protein Interacting Protein Info
UniProt ID
POTE1_HUMAN 
Synonyms CMM10; HPOT1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [4]
4 Affinity Capture-MS [5]
Interacting Protein Name Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) Interacting Protein Interacting Protein Info
UniProt ID
TE2IP_HUMAN 
Synonyms DRIP5; RAP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [20]
4 Co-localization [20]
References  Top
REF 1 The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. PLoS One. 2010 Aug 25;5(8):e12407.
REF 2 Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics. 2011 Feb;10(2):M110.001628.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 5 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 6 The F-box protein -TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells. Biochem Biophys Res Commun. 2013 May 17;434(4):728-34.
REF 7 GDP-mannose-4,6-dehydratase is a cytosolic partner of tankyrase 1 that inhibits its poly(ADP-ribose) polymerase activity. Mol Cell Biol. 2012 Aug;32(15):3044-53.
REF 8 TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex. Nat Genet. 2004 Jun;36(6):618-23.
REF 9 Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol Cell Biol. 2002 Jan;22(1):332-42.
REF 10 The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). J Biol Chem. 2002 Apr 19;277(16):14116-26.
REF 11 Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J. 2002 Feb 1;361(Pt 3):451-9.
REF 12 Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a nov... J Biol Chem. 2002 Aug 30;277(35):31887-92.
REF 13 Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science. 1998 Nov 20;282(5393):1484-7.
REF 14 Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles. J Biol Chem. 2000 Dec 8;275(49):38437-44.
REF 15 TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. J Biol Chem. 2001 Sep 21;276(38):35891-9.
REF 16 Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J Biol Chem. 2001 Aug 3;276(31):29282-91.
REF 17 Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59.
REF 18 Nuclear import pathway of the telomere elongation suppressor TRF1: inhibition by importin alpha. Biochemistry. 2002 Jul 30;41(30):9333-40.
REF 19 GNL3L stabilizes the TRF1 complex and promotes mitotic transition. J Cell Biol. 2009 Jun 1;185(5):827-39.
REF 20 TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem. 2004 Nov 5;279(45):47264-71.
REF 21 TIN2, a new regulator of telomere length in human cells. Nat Genet. 1999 Dec;23(4):405-12.
REF 22 A human protein-protein interaction network: a resource for annotating the proteome. Cell. 2005 Sep 23;122(6):957-68.
REF 23 The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. J Biol Chem. 2006 Jan 13;281(2):759-68.
REF 24 The splicing factor U2AF65 stabilizes TRF1 protein by inhibiting its ubiquitin-dependent proteolysis. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1124-30.
REF 25 Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1. Mol Cell. 2017 Mar 2;65(5):818-831.e5.
REF 26 Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell. 2010 Feb 16;18(2):214-25.
REF 27 Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase. J Biol Chem. 2010 Apr 30;285(18):13896-906.
REF 28 Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1. J Biol Chem. 2009 Mar 27;284(13):8557-66.
REF 29 The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell. 2001 Nov 2;107(3):347-59.
REF 30 NEDD8 ultimate buster-1 regulates the abundance of TRF1 at telomeres by promoting its proteasomal degradation. FEBS Lett. 2016 Jun;590(12):1776-90.

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