Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T64682 Target Info
Target Name Serine/threonine-protein kinase Sgk1 (SGK1)
Synonyms Serum/glucocorticoid-regulated kinase 1; SGK1
Target Type Clinical trial Target
Gene Name SGK1
Biochemical Class Kinase
UniProt ID
SGK1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) Interacting Protein Interacting Protein Info
UniProt ID
NED4L_HUMAN 
Synonyms NEDD4.2; NEDD4.2; RSP5; hNEDD4.2
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [3]
4 Biochemical Activity [4]
5 Biochemical Activity [5]
6 Biochemical Activity [6]
Interacting Target Name E3 ubiquitin-protein ligase NEDD4 (NEDD4) Literature-reported Target Interacting Protein Info
UniProt ID
NEDD4_HUMAN 
Synonyms Neural precursor cell expressed developmentally down-regulated protein 4; NEDD4-1; NEDD-4; KIAA0093; HECT-type E3 ubiquitin transferase NEDD4; Cell proliferation-inducing gene 53 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [7]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name SRY-interacting protein 1 (SLC9A3R2) Interacting Protein Interacting Protein Info
UniProt ID
NHRF2_HUMAN 
Synonyms E3KARP; NHE3RF2; NHERF.2; NHERF2; OCTS2; SIP.1; SIP1; TKA.1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [9]
3 Reconstituted Complex [9]
Kinases [+] 1 Kinases +
Interacting Target Name Phosphoinositide dependent protein kinase-1 (PDPK1) Clinical trial Target Interacting Protein Info
UniProt ID
PDPK1_HUMAN 
Synonyms PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [10]
2 Reconstituted Complex [11]
References  Top
REF 1 Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One. 2010 Aug 13;5(8):e12163.
REF 2 The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. J Biol Chem. 2013 May 24;288(21):15075-84.
REF 3 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels. Biochemistry. 2006 May 30;45(21):6733-40.
REF 4 Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. J Biol Chem. 2010 Aug 13;285(33):25161-7.
REF 5 WNK1 activates SGK1 to regulate the epithelial sodium channel. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10315-20.
REF 6 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell. 2009 Nov 13;36(3):457-68.
REF 7 Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem. 2002 Jan 4;277(1):5-8.
REF 8 Glucocorticoid activation of Na(+)/H(+) exchanger isoform 3 revisited. The roles of SGK1 and NHERF2. J Biol Chem. 2002 Mar 8;277(10):7676-83.
REF 9 The Na(+)/H(+) exchanger regulatory factor 2 mediates phosphorylation of serum- and glucocorticoid-induced protein kinase 1 by 3-phosphoinositide-dependent protein kinase 1. Biochem Biophys Res Commun. 2002 Oct 25;298(2):207-15.
REF 10 NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function. J Biol Chem. 2007 Nov 30;282(48):35293-307.
REF 11 Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 1999 Jun 1;18(11):3024-33.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.