Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T65889 | Target Info | |||
| Target Name | Pyruvate kinase M2 (PKM) | ||||
| Synonyms | p58; Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase PKM; Pyruvate kinase 2/3; PKM2; PK3; PK2; Opa-interacting protein 3; OIP3; OIP-3; Cytosolic thyroid hormone-binding protein; CTHBP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PKM | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Isomerases | [+] 1 Isomerases | + | |||
| Interacting Target Name | Rotamase Pin1 (PIN1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Prolyl isomerase Pin1; PPIase Pin1; Peptidyl-prolyl cis-trans isomerase Pin1; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl prolyl cis/trans isomerase Pin1 | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Biochemical Activity | [1] | |||
| 3 | Protein-peptide | [1] | |||
| 4 | Reconstituted Complex | [2] | |||
| 5 | Yeast two hybrid | [3] | |||
| Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
| Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
| Evidence Score (E-score) | 1 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [4] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [5] | |||
| 2 | Reconstituted Complex | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec;14(12):1295-304. | ||||
| REF 2 | WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol. 2005 Aug;25(16):7092-106. | ||||
| REF 3 | A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8. | ||||
| REF 4 | A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289. | ||||
| REF 5 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
| REF 6 | PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun. 2016 Aug 3;7:12431. | ||||
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