Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T65889 Target Info
Target Name Pyruvate kinase M2 (PKM)
Synonyms p58; Tumor M2-PK; Thyroid hormone-binding protein 1; THBP1; Pyruvate kinase muscle isozyme; Pyruvate kinase isozymes M1/M2; Pyruvate kinase PKM; Pyruvate kinase 2/3; PKM2; PK3; PK2; Opa-interacting protein 3; OIP3; OIP-3; Cytosolic thyroid hormone-binding protein; CTHBP
Target Type Clinical trial Target
Gene Name PKM
Biochemical Class Kinase
UniProt ID
KPYM_HUMAN 
Target Interacting Proteins  Top
Isomerases [+] 1 Isomerases +
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Other proteins [+] 1 Other proteins +
References  Top
REF 1 ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec;14(12):1295-304.
REF 2 WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol. 2005 Aug;25(16):7092-106.
REF 3 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 4 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.
REF 5 Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4.
REF 6 PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun. 2016 Aug 3;7:12431.

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