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| Target General Information |
Top |
| Target ID |
T67103 |
Target Info
|
| Target Name |
Integrin alpha-V (ITGAV) |
| Synonyms |
Vitronectin receptor subunit alpha; Vitronectin receptor alpha subunit; Vitronectin receptor; VTNR; VNRA; MSK8; CD51 antigen; CD51 |
| Target Type |
Clinical trial Target |
| Gene Name |
ITGAV |
| Biochemical Class |
Integrin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Integrins |
[+] 2 Integrins |
+ |
| Interacting Target Name |
Integrin beta-3 (ITGB3) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Platelet membrane glycoprotein IIIa; Integrin beta-3; GPIIIa; GP3A; CD61 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Co-crystal Structure |
[2] |
| 3 |
Co-localization |
[3] |
| Interacting Target Name |
Integrin beta-1 (ITGB1) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
VLA-4 subunit beta; MSK12; MDF2; Integrin VLA-4 beta subunit; GPIIA; Glycoprotein IIa; FNRB; Fibronectin receptor subunit beta; Fibronectin receptor beta subunit; CD29 antigen; CD29; Beta(1) integrin |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Co-fractionation |
[4] |
| 2 |
Co-localization |
[3] |
| References |
Top |
| REF 1 |
A Leu262Pro mutation in the integrin beta(3) subunit results in an alpha(IIb)-beta(3) complex that binds fibrin but not fibrinogen. Blood. 2000 Jul 1;96(1):161-9.
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| REF 2 |
Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Science. 2002 Apr 5;296(5565):151-5.
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| REF 3 |
COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol. 2015 Mar;24(1):55-70.
|
| REF 4 |
Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
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