Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82685 | Target Info | |||
| Target Name | Junction plakoglobin (JUP) | ||||
| Synonyms | Plakoglobin; Desmoplakin-3; Desmoplakin III; DP3; Catenin gamma; CTNNG | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | JUP | ||||
| Biochemical Class | Beta-catenin | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 2 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Protein-Fragment Complementation Assay | [2] | |||
| 3 | Reconstituted Complex | [3] | |||
| 4 | Yeast two hybrid | [4] | |||
| Interacting Target Name | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-localization | [5] | |||
| 2 | Far Western | [6] | |||
| Other proteins | [+] 6 Other proteins | + | |||
| Interacting Target Name | Epithelial cadherin (CDH1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Uvomorulin; UVO; E-cadherin gene; E-cadherin; CDHE; CD324; CAM 120/80; Cadherin-1 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Affinity Capture-Western | [8] | |||
| 3 | Proximity Label-MS | [9] | |||
| 4 | Reconstituted Complex | [10] | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [7] | |||
| 2 | Affinity Capture-Western | [11] | |||
| 3 | Co-localization | [5] | |||
| Interacting Target Name | Neural cadherin (CDH2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | N-cadherin; NCAD; CDw325; CDHN; CD325; Cadherin-2 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [12] | |||
| 2 | Affinity Capture-Western | [13] | |||
| 3 | Co-fractionation | [14] | |||
| Interacting Protein Name | Catenin alpha-1 (CTNNA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CAP102 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [15] | |||
| 2 | Co-localization | [5] | |||
| 3 | Reconstituted Complex | [16] | |||
| Interacting Protein Name | Adenomatous polyposis coli protein (APC) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BTPS2; DP2; DP2.5; DP3; GS; PPP1R46 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Co-localization | [5] | |||
| 2 | Reconstituted Complex | [10] | |||
| Interacting Protein Name | Desmoglein-2 (DSG2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ARVC10; ARVD10; CDHF5; CMD1BB; HDGC | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [17] | |||
| 2 | Reconstituted Complex | [18] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Mol Cell Proteomics. 2014 Jul;13(7):1644-58. | ||||
| REF 2 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92. | ||||
| REF 3 | The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J Biol Chem. 1998 Apr 10;273(15):9078-84. | ||||
| REF 4 | In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84. | ||||
| REF 5 | Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46. | ||||
| REF 6 | c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem Biophys Res Commun. 1995 Mar 28;208(3):1067-72. | ||||
| REF 7 | Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in -Catenin-Active Cancers. Cell Syst. 2016 Sep 28;3(3):302-316.e4. | ||||
| REF 8 | Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol. 1994 Jun;125(6):1327-40. | ||||
| REF 9 | E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal. 2014 Dec 2;7(354):rs7. | ||||
| REF 10 | Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation. Biochem Biophys Res Commun. 1994 Aug 30;203(1):519-22. | ||||
| REF 11 | Expression and interaction of different catenins in colorectal carcinoma cells. Int J Mol Med. 2001 Dec;8(6):695-8. | ||||
| REF 12 | A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells. J Cell Sci. 2003 Dec 15;116(Pt 24):4985-95. | ||||
| REF 13 | Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem. 1995 Aug 25;270(34):20201-6. | ||||
| REF 14 | A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81. | ||||
| REF 15 | A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity. Cell Adhes Commun. 1998 Jun;5(4):283-96. | ||||
| REF 16 | Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). J Biol Chem. 1997 Apr 25;272(17):11017-20. | ||||
| REF 17 | The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2. J Cell Sci. 2000 May;113 ( Pt 10):1737-45. | ||||
| REF 18 | The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high affinity binding to the cytoplasmic domains of E-cadherin and desmosomal cadherin Dsg2, and the tumor suppressor APC protein. J Biochem. 1995 Nov;118(5):1077-82. | ||||
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