Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T92328 Target Info
Target Name Ryanodine receptor 1 (RYR1)
Synonyms Type 1 ryanodine receptor; Skeletal muscle-type ryanodine receptor; Skeletal muscle ryanodine receptor; Skeletal muscle calcium release channel; RyR1; RyR; RYR-1; RYDR; Cardiac muscleryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; Brain-type ryanodine receptor; Brain ryanodine receptor-calcium release channel
Target Type Discontinued Target
Gene Name RYR1
Biochemical Class Ryanodine-inositol 1,4,5-triphosphate receptor calcium channel
UniProt ID
RYR1_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Triadin (TRDN) Interacting Protein Interacting Protein Info
UniProt ID
TRDN_HUMAN 
Synonyms CPVT5; TDN; TRISK
Evidence Score (E-score) 2 Experimental Evidences +
1 Far Western [1]
2 Reconstituted Complex [2]
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 1A (FKBP1A) Successful Target Interacting Protein Info
UniProt ID
FKB1A_HUMAN 
Synonyms Rotamase; PPIase FKBP1A; Peptidyl-prolyl cis-trans isomerase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP-1A; FKBP-12; FKBP12; FKBP1; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [5]
References  Top
REF 1 Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. J Biol Chem. 1999 Apr 30;274(18):12278-83.
REF 2 Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. J Biol Chem. 2004 Feb 20;279(8):6994-7000.
REF 3 FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20;278(25):22600-8.
REF 4 Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor. Biochem J. 2001 Mar 1;354(Pt 2):413-22.
REF 5 FKBP12 binding modulates ryanodine receptor channel gating. J Biol Chem. 2001 May 18;276(20):16931-5.

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