Protein-Protein Interaction Details
| Protein General Information (TTD Target) | Top | ||||
|---|---|---|---|---|---|
| Full Name | FK506-binding protein 1A (FKBP1A) | Successful | Target Info | ||
| UniProt ID | FKB1A_HUMAN | ||||
| Gene Name | FKBP1A | ||||
| Gene ID | 2280 | ||||
| Interacting TTD Target Information | Top | ||||
|---|---|---|---|---|---|
| Interacting Successful Target(s) | Serine/threonine-protein kinase mTOR (mTOR) | Target Info | PPI Info | [1] | |
| Interacting Clinical trial Target(s) | TGF-beta receptor type I (TGFBR1) | Target Info | PPI Info | [2] | |
| Interacting Discontinued Target(s) | Ryanodine receptor 1 (RYR1) | Target Info | PPI Info | [3] | |
| Interacting Patented-recorded Target(s) | Activin receptor type IB (ACVR1B) | Target Info | PPI Info | [4] | |
| Interacting Literature-reported Target(s) | IP3 receptor isoform 1 (ITPR1) | Target Info | PPI Info | [5] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol. 2010 Sep 24;17(9):1018-29. | ||||
| REF 2 | Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science. 1994 Jul 29;265(5172):674-6. | ||||
| REF 3 | FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20;278(25):22600-8. | ||||
| REF 4 | FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006 Jun;36(3):569-79. | ||||
| REF 5 | In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005 Dec 1;118(Pt 23):5443-51. | ||||
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