Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95371 | Target Info | |||
| Target Name | Interferon alpha/beta receptor 1 (IFNAR1) | ||||
| Synonyms | Type I interferon receptor 1; IFNalpha/beta receptor 1; IFNR1; IFNAR; IFN-alpha/beta receptor 1; IFN-R-1; Cytokine receptor family 2 member 1; Cytokine receptor classII member 1; Cytokine receptor class-II member 1; CRF21; CRF2-1 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | IFNAR1 | ||||
| Biochemical Class | Cytokine receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Cytokine receptors | [+] 1 Cytokine receptors | + | |||
| Interacting Target Name | Interferon alpha/beta receptor 2 (IFNAR2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Type I interferon receptor 2; Type I interferon receptor; Interferon alpha/beta receptor; Interferon alpha binding protein; IFN-R-2; IFN-R; IFNARB; IFN-alpha-REC; IFN-alpha/beta receptor 2; IFN-alpha binding protein; IFNABR | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Co-localization | [2] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | TYK2 tyrosine kinase (TYK2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Nonreceptor tyrosineprotein kinase TYK2 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Affinity Capture-Western | [5] | |||
| 4 | Reconstituted Complex | [6] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Signal transducer and activator of transcription 2 (STAT2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ISGF.3; P113; STAT113 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Reconstituted Complex | [8] | |||
| 4 | Reconstituted Complex | [9] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Protein Name | F-box/WD repeat-containing protein 11 (FBXW11) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [10] | |||
| 3 | Reconstituted Complex | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Rep. 2013 Oct 17;5(1):180-93. | ||||
| REF 2 | Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling. J Cell Biol. 2015 May 25;209(4):579-93. | ||||
| REF 3 | Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem. 2008 Jul 4;283(27):18566-72. | ||||
| REF 4 | Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor. J Biol Chem. 2004 Nov 5;279(45):46614-20. | ||||
| REF 5 | Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice. J Immunol. 2004 Sep 15;173(6):3863-70. | ||||
| REF 6 | Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 1998 Sep 18;273(38):24723-9. | ||||
| REF 7 | Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. J Biol Chem. 1995 Oct 20;270(42):24627-30. | ||||
| REF 8 | Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol. 1997 Apr;17(4):2048-56. | ||||
| REF 9 | Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 1996 Mar 1;15(5):1064-74. | ||||
| REF 10 | Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis. J Cell Biol. 2007 Dec 3;179(5):935-50. | ||||
| REF 11 | SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 2003 Oct 15;22(20):5480-90. | ||||
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