Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T04507 | ||||
Target Name | Presynaptic density protein 95 (DLG4) | ||||
Type of Target |
Clinical trial |
||||
Drug Potency against Target | FETAV | Drug Info | Ki = 2300 nM | [1] | |
KSG-LDTKNYKQTSV | Drug Info | Ki = 2100 nM | [1] | ||
KSG-YEKLSSIESDV | Drug Info | Ki = 7000 nM | [1] | ||
N-(3,4-Dichlorophenyl)propyl-ETAV | Drug Info | Ki = 1100 nM | [1] | ||
N-(3,4-Difluorophenyl)propyl-ETAV | Drug Info | Ki = 1000 nM | [1] | ||
N-(Naphthalene-2-yl)ethyl-ETAV | Drug Info | Ki = 950 nM | [1] | ||
N-Benzyl-ETAV | Drug Info | Ki = 5200 nM | [1] | ||
N-Butyl-ETAV | Drug Info | Ki = 4000 nM | [1] | ||
N-Cyclohexylethyl-ETAV | Drug Info | Ki = 450 nM | [1] | ||
N-Cyclohexylmethyl-ETAV | Drug Info | Ki = 1300 nM | [1] | ||
N-Ethyl-ETAV | Drug Info | Ki = 9600 nM | [1] | ||
N-Methyl-ETAV | Drug Info | Ki = 8900 nM | [1] | ||
N-Phenylethyl-ETAV | Drug Info | Ki = 1600 nM | [1] | ||
N-Phenylpropyl-ETAV | Drug Info | Ki = 3100 nM | [1] | ||
N-Propyl-ETAV | Drug Info | Ki = 4200 nM | [1] | ||
YGRKKRRQRRR-KLSSIESDV | Drug Info | Ki = 14000 nM | [1] | ||
References | |||||
REF 1 | Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.