Target Validation Information
TTD ID T04507
Target Name Presynaptic density protein 95 (DLG4)
Type of Target
Clinical trial
Drug Potency against Target FETAV Drug Info Ki = 2300 nM [1]
KSG-LDTKNYKQTSV Drug Info Ki = 2100 nM [1]
KSG-YEKLSSIESDV Drug Info Ki = 7000 nM [1]
N-(3,4-Dichlorophenyl)propyl-ETAV Drug Info Ki = 1100 nM [1]
N-(3,4-Difluorophenyl)propyl-ETAV Drug Info Ki = 1000 nM [1]
N-(Naphthalene-2-yl)ethyl-ETAV Drug Info Ki = 950 nM [1]
N-Benzyl-ETAV Drug Info Ki = 5200 nM [1]
N-Butyl-ETAV Drug Info Ki = 4000 nM [1]
N-Cyclohexylethyl-ETAV Drug Info Ki = 450 nM [1]
N-Cyclohexylmethyl-ETAV Drug Info Ki = 1300 nM [1]
N-Ethyl-ETAV Drug Info Ki = 9600 nM [1]
N-Methyl-ETAV Drug Info Ki = 8900 nM [1]
N-Phenylethyl-ETAV Drug Info Ki = 1600 nM [1]
N-Phenylpropyl-ETAV Drug Info Ki = 3100 nM [1]
N-Propyl-ETAV Drug Info Ki = 4200 nM [1]
YGRKKRRQRRR-KLSSIESDV Drug Info Ki = 14000 nM [1]
References
REF 1 Modified peptides as potent inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction. J Med Chem. 2008 Oct 23;51(20):6450-9.

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