Target Validation Information
TTD ID	T10191
Target Name	T-cell surface glycoprotein CD4 (CD4)
Type of Target	Successful
Action against Disease Model	TNX-355	Drug Info	Hu5A8 is a molecularly engineered h uMan IgG4 antibody retaining the binding and functional properties of the murine version of 5A8 (mu5A8). This h uManized MAb has been shown to be very effective in inhibiting HIV-1 infection of h uMan CD4+ T cells and macrophages in vitro and to reduce viral load in rhesus monkeys chronically infected with simian immunodeficiency virus (SIV).	[1]
References
REF 1	Development of anti-CD4 MAb hu5A8 for treatment of HIV-1 infection: preclinical assessment in non-human primates. Toxicology. 2002 Apr 2;172(3):191-203.

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