| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T12119 | ||||
| Target Name | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | 4-(2'-(trifluoromethoxy)biphenyl-3-yl)oxazole | Drug Info | IC50 = 1940 nM | [1] | |
| 4-(2'-(trifluoromethoxy)biphenyl-3-yl)thiazole | Drug Info | IC50 = 2160 nM | [1] | ||
| 4-(2'-(trifluoromethyl)biphenyl-3-yl)oxazole | Drug Info | IC50 = 5310 nM | [1] | ||
| V-102862 | Drug Info | Ki = 360 nM | [1] | ||
| References | |||||
| REF 1 | Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5536-40. | ||||
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