Target Validation Information
TTD ID	T13714
Target Name	Oxysterols receptor LXR-beta (NR1H2)
Type of Target	Clinical trial
Drug Potency against Target		Drug Info	IC50 = 24 nM	[3]
	12,17-dehydroxyriccardin C	Drug Info	IC50 = 14000 nM	[1]
	12-dehydroxyriccardin C	Drug Info	IC50 = 7600 nM	[1]
	17-dehydroxyriccardin C	Drug Info	IC50 = 13000 nM	[1]
	2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole	Drug Info	IC50 = 41 nM	[3]
	4,17-dehydroxyriccardin C	Drug Info	IC50 = 7300 nM	[1]
	4-dehydroxyriccardin C	Drug Info	IC50 = 10000 nM	[1]
	GSK-9772	Drug Info	IC50 = 30 nM	[2]
	GW-3965	Drug Info	IC50 = 12 nM	[3]
	Riccardin C	Drug Info	IC50 = 6600 nM	[1]
	WAY-214950	Drug Info	IC50 = 33 nM	[3]
References
REF 1	Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85.
REF 2	Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem. 2008 Sep 25;51(18):5758-65.
REF 3	Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8.

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