Target Validation Information
TTD ID	T17980
Target Name	Fyn tyrosine protein kinase (FYN)
Type of Target	Successful
Drug Potency against Target	Dasatinib	Drug Info	Kd = 0.79 nM	[4]
	CEP-5104	Drug Info	IC50 = 3400 nM	[3]
	CEP-6331	Drug Info	IC50 = 1190 nM	[3]
	JNJ-10198409	Drug Info	IC50 = 378 nM	[1]
	Ro-4396686	Drug Info	IC50 = 466 nM	[2]
References
REF 1	(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73.
REF 2	Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3.
REF 3	Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.
REF 4	A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008 Jan;26(1):127-32.

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