Target Validation Information
TTD ID T17980
Target Name Fyn tyrosine protein kinase (FYN)
Type of Target
Drug Potency against Target Dasatinib Drug Info Kd = 0.79 nM [4]
CEP-5104 Drug Info IC50 = 3400 nM [3]
CEP-6331 Drug Info IC50 = 1190 nM [3]
JNJ-10198409 Drug Info IC50 = 378 nM [1]
Ro-4396686 Drug Info IC50 = 466 nM [2]
REF 1 (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad ant... J Med Chem. 2005 Dec 29;48(26):8163-73.
REF 2 Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3.
REF 3 Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.
REF 4 A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol. 2008 Jan;26(1):127-32.

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