| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T30520 | ||||
| Target Name | Bacterial RNA polymerase switch region (Bact RNAP-SR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Rifampin | Drug Info | MIC = 0.1~2 ug/ml | [1] | |
| Rifampin | Drug Info | Ic50 = 2 nM | [2] | ||
| References | |||||
| REF 1 | New anti-tuberculosis drugs with novel mechanisms of action. Curr Med Chem. 2008;15(19):1956-67. | ||||
| REF 2 | Role of an RNA polymerase interacting protein, MsRbpA, from Mycobacterium smegmatis in phenotypic tolerance to rifampicin. Microbiology. 2010 Mar;156(Pt 3):873-83. | ||||
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