Target Validation Information
TTD ID	T31514
Target Name	Lysosomal alpha-glucosidase (GAA)
Type of Target	Successful
Drug Potency against Target	Acarbose	Drug Info	IC50 = 430 nM	[8]
	(-)-uniflorine A	Drug Info	IC50 = 12000 nM	[4]
	(R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol	Drug Info	IC50 = 2700 nM	[7]
	2,5-imino-2,5,6-trideoxy-D-manno-heptitol	Drug Info	IC50 = 7200 nM	[6]
	7-O-b-D-Glucopyranosyl-a-homonojirimycin	Drug Info	IC50 = 380 nM	[3]
	Alpha-7-Deoxyhomonojirimycin	Drug Info	IC50 = 19000 nM	[1]
	Alpha-Homonojirimycin	Drug Info	IC50 = 80 nM	[3]
	Deoxynojirimycin	Drug Info	IC50 = 130 nM	[3]
	N-adamantanemethyloxypentyl-1-deoxynojirimycin	Drug Info	IC50 = 400 nM	[5]
	SALACINOL	Drug Info	Ki = 970 nM	[2]
	UNIFLORINE B	Drug Info	IC50 = 4000 nM	[4]
	VALIOLAMINE	Drug Info	IC50 = 18000 nM	[3]
Action against Disease Model	Acarbose	Drug Info	Acarbose attenuates postprandial hyperlipidemia in an intestinal absorptive cell model, Exposure of Caco-2 cells to acarbose at a concentration of 10 mmol/L reduced oleic acid absorption by 30%, triglyceride-rich lipoprotein secretion by around 10%, and apo B-48 secretion by 50%, whereas apo A-I secretion was not affected	[9]
References
REF 1	New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica. J Nat Prod. 2002 Dec;65(12):1875-81.
REF 2	Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT). J Nat Prod. 2008 Jun;71(6):981-4.
REF 3	In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
REF 4	Total synthesis of (-)-uniflorine A. J Nat Prod. 2009 Nov;72(11):2058-60.
REF 5	Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6600-3.
REF 6	Nitrogen-containing furanose and pyranose analogues from Hyacinthus orientalis. J Nat Prod. 1998 May;61(5):625-8.
REF 7	Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases. J Med Chem. 1998 Jul 2;41(14):2565-71.
REF 8	Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action. Biosci Biotechnol Biochem. 2002 Mar;66(3):689-92.
REF 9	Acarbose attenuates postprandial hyperlipidemia: investigation in an intestinal absorptive cell model. Metabolism. 2009 May;58(5):583-5.

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