Target Validation Information
TTD ID	T34429
Target Name	Neuronal acetylcholine receptor alpha-7 (CHRNA7)
Type of Target	Successful
Drug Potency against Target	ALCURONIUM	Drug Info	IC50 = 4100 nM	[3]
	CP-810123	Drug Info	Ki = 16.4 nM	[5]
	CYTISINE	Drug Info	Ki = 1420 nM	[2]
	GCCSHPACAGNNQHIC*	Drug Info	IC50 = 1.1 nM	[1]
	GCCSNPVCHLEHSNLC*	Drug Info	IC50 = 8 nM	[1]
	PH-709829	Drug Info	Ki = 9 nM	[4]
	TOXIFERINE	Drug Info	IC50 = 9500 nM	[3]
References
REF 1	Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem. 2005 Jul 28;48(15):4705-45.
REF 2	3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4889-97.
REF 3	Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine re... J Med Chem. 2007 Sep 20;50(19):4616-29.
REF 4	Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor:... Bioorg Med Chem Lett. 2008 Jun 15;18(12):3611-5.
REF 5	Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor ag... J Med Chem. 2010 Feb 11;53(3):1222-37.

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