Target Validation Information
TTD ID	T38338
Target Name	Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)
Type of Target	Successful
Drug Potency against Target	Ziconotide	Drug Info	IC50 = 0.005 mcg/ml	[6]
	Cilnidipine	Drug Info	IC50 = 200 nM	[8]
	Ralfinamide	Drug Info	IC50 = 10000 nM	[7]
	GNF-PF-3464	Drug Info	IC50 = 14000 nM	[4]
	Hesperidin	Drug Info	IC50 = 9500 nM	[4]
	LOMERIZINE	Drug Info	IC50 = 2430 nM	[3]
	NSC-180246	Drug Info	IC50 = 13100 nM	[4]
	NSC-87509	Drug Info	IC50 = 12500 nM	[4]
	PD-151307	Drug Info	IC50 = 320 nM	[2]
	PD-157667	Drug Info	IC50 = 460 nM	[1]
	PD-167341	Drug Info	IC50 = 590 nM	[2]
	PD-29361	Drug Info	IC50 = 4400 nM	[5]
	PD-32577	Drug Info	IC50 = 970 nM	[1]
References
REF 1	Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.
REF 2	Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic proper... J Med Chem. 1999 Oct 7;42(20):4239-49.
REF 3	Synthesis and SAR of novel 2-arylthiazolidinones as selective analgesic N-type calcium channel blockers. Bioorg Med Chem Lett. 2007 Feb 1;17(3):662-7.
REF 4	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
REF 5	Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2415-8.
REF 6	Bacterial ribosomal subunit assembly is an antibiotic target. Curr Top Med Chem. 2003;3(9):929-47.
REF 7	The anti-nociceptive agent ralfinamide inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive Na+ currents in dorsal root ganglion neurons. Eur J Pharmacol. 2005 Mar 14;510(3):197-208.
REF 8	Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1997 Mar;280(3):1184-91.

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