Target Validation Information
TTD ID T50688
Target Name Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)
Type of Target
Successful
Drug Potency against Target Abciximab Drug Info KD = 8.5+/-5.6 nM/L [2]
Eptifibatide Drug Info Kd = 120 nM/L [1]
Tirofiban Drug Info Kd = 15 nM/L [1]
References
REF 1 Platelet glycoprotein IIb/IIIa antagonists. What are the relevant issues concerning their pharmacology and clinical use Circulation. 1999 Jul 27;100(4):437-44.
REF 2 Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins. Circulation. 1998 Sep 15;98(11):1085-91.

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