| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T51426 | ||||
| Target Name | Farnesoid X-activated receptor (FXR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | 12-O-deacetyl-12-epi-19-deoxy-21-hydroxyscalarin | Drug Info | IC50 = 2400 nM | [2] | |
| AGN-34 | Drug Info | IC50 < 10 nM | [1] | ||
| Guggulsterone | Drug Info | IC50 = 4100 nM | [2] | ||
| References | |||||
| REF 1 | Farnesoid X receptor: from structure to potential clinical applications. J Med Chem. 2005 Aug 25;48(17):5383-403. | ||||
| REF 2 | Scalarane sesterterpenes from a marine sponge of the genus Spongia and their FXR antagonistic activity. J Nat Prod. 2007 Nov;70(11):1691-5. | ||||
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