Target Validation Information
TTD ID	T52189
Target Name	ATP-citrate synthase (ACLY)
Type of Target	Successful
Drug Potency against Target	(-)-hydroxycitrate	Drug Info	Ki = 150 nM	[3]
	(-)-hydroxycitrate	Drug Info	IC50 = 150 nM	[1]
	SB-201076	Drug Info	Ki = 1000 nM	[2]
References
REF 1	2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.
REF 2	The biology and chemistry of hyperlipidemia. Bioorg Med Chem. 2007 Jul 15;15(14):4674-99.
REF 3	Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based... J Med Chem. 1995 Feb 3;38(3):537-43.

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