| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T56915 | ||||
| Target Name | Human immunodeficiency virus Protease (HIV PR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Amprenavir | Drug Info | EC50 = 78 nM | [1] | |
| Indinavir | Drug Info | EC50 = 41 nM | [1] | ||
| Ritonavir | Drug Info | EC50 = 68 nM | [1] | ||
| Saquinavir | Drug Info | EC50 = 14 nM | [1] | ||
| Tipranavir | Drug Info | Ki = 1 nM | [2] | ||
| References | |||||
| REF 1 | Peptidomimetic inhibitors of HIV protease. Curr Top Med Chem. 2004;4(10):1079-95. | ||||
| REF 2 | Non-peptidic HIV protease inhibitors. Curr Top Med Chem. 2004;4(10):1097-114. | ||||
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