Target Validation Information
TTD ID	T58921
Target Name	Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Type of Target	Successful
Drug Potency against Target	Pioglitazone	Drug Info	EC50 = 580 nM	[3]
	Rosiglitazone XR	Drug Info	EC50 = 40 nM	[3]
	Netoglitazone	Drug Info	EC50 = 100 nM	[2]
	Rosiglitazone + metformin	Drug Info	EC50 = 200 nM	[5]
	Rosiglitazone + simvastatin	Drug Info	IC50 = 23 nM	[4]
	TESAGLITAZAR	Drug Info	Ki = 200 nM	[1]
References
REF 1	Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes. J Med Chem. 2004 Aug 12;47(17):4118-27.
REF 2	Treatment of non-insulin-dependent diabetes mellitus. Expert Opin Investig Drugs. 2003 Apr;12(4):623-33.
REF 3	Nuclear receptors as potential targets for modulating reverse cholesterol transport. Curr Top Med Chem. 2005;5(3):265-82.
REF 4	Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. Curr Opin Pharmacol. 2005 Aug;5(4):366-73.
REF 5	A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem. 1998 Dec 4;273(49):32679-84.

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