| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T71192 | ||||
| Target Name | Leukotriene CysLT1 receptor (CYSLTR1) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Pranlukast | Drug Info | IC50 = 300 nM | [1] | |
| Zafirlukast | Drug Info | IC50 = 600 nM | [1] | ||
| References | |||||
| REF 1 | Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro. Br J Pharmacol. 1998 Jun;124(3):563-71. | ||||
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