Target Validation Information
TTD ID	T78429
Target Name	Inhibitor of nuclear factor kappa-B kinase beta (IKKB)
Type of Target	Clinical trial
Drug Potency against Target	2-amino-5-phenylthiophene-3-carboxamide	Drug Info	IC50 = 1900 nM	[1]
	2-amino-quinoline-3-carboxylic acid amide	Drug Info	IC50 = 9600 nM	[1]
	3-amino-5-(4-chlorophenyl)thiophene-2-carboxamide	Drug Info	IC50 = 6600 nM	[1]
	3-amino-benzo[b]thiophene-2-carboxylic acid amide	Drug Info	IC50 = 12600 nM	[1]
	4-amino-biphenyl-3-carboxylic acid amide	Drug Info	IC50 = 14500 nM	[1]
	5-amino-2-p-tolyl-oxazole-4-carboxylic acid amide	Drug Info	IC50 = 12700 nM	[1]
	5-amino-2-phenyl-oxazole-4-carboxylic acid amide	Drug Info	IC50 = 11000 nM	[1]
	6-phenyl-thieno[3,2-d]pyrimidin-4-ylamine	Drug Info	IC50 = 970 nM	[1]
	SC-514	Drug Info	IC50 = 2000 nM	[2]
References
REF 1	Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies. J Med Chem. 2006 May 18;49(10):2898-908.
REF 2	The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.