| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T82266 | ||||
| Target Name | Voltage-gated L-type calcium channel (L-CaC) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Bepridil | Drug Info | IC50 = 500 nM | [2] | |
| Cilnidipine | Drug Info | IC50 = 100 nM | [3] | ||
| Pinaverium bromide | Drug Info | Ki = 40 nM | [1] | ||
| References | |||||
| REF 1 | N-methyl-D-aspartate receptor (NMDA) antagonists as potential pain therapeutics. Curr Top Med Chem. 2006;6(8):749-70. | ||||
| REF 2 | Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17. | ||||
| REF 3 | Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1997 Mar;280(3):1184-91. | ||||
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