Target Validation Information
TTD ID	T84040
Target Name	Transformation-sensitive protein p120 (TRPA1)
Type of Target	Successful
Drug Potency against Target	2-methyl-1-(pyridin-3-yl)pent-1-en-3-one oxime	Drug Info	IC50 = 17000 nM
	2-methyl-1-(pyridin-4-yl)pent-1-en-3-one oxime	Drug Info	IC50 = 8610 nM
	2-methyl-1-(thiophen-2-yl)pent-1-en-3-one oxime	Drug Info	IC50 = 11000 nM
	2-methyl-1-(thiophen-3-yl)pent-1-en-3-one oxime	Drug Info	IC50 = 1320 nM
	3-Methyl-4-phenylbut-3-en-2-one oxime	Drug Info	IC50 = 2700 nM	[1]
	AMG-2504	Drug Info	IC50 = 105 nM
	AMG-5445	Drug Info	IC50 = 29 nM
	AMG-7160	Drug Info	IC50 = 28 nM
	AMG-9090	Drug Info	IC50 = 7 nM
	AP18	Drug Info	IC50 = 4500 nM
References
REF 1	Oxime derivatives related to AP18: Agonists and antagonists of the TRPA1 receptor. Bioorg Med Chem Lett. 2010 Jan 1;20(1):276-9.

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