| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T85605 | ||||
| Target Name | 5-HT receptor (5HTR) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Fenfluramine | Drug Info | IC50 = 11 nM | [3] | |
| Bifeprunox | Drug Info | Ki = 1.48 nM | [1] | ||
| Palbociclib | Drug Info | IC50 = 11 nM | [2] | ||
| References | |||||
| REF 1 | Novel antipsychotics activate recombinant human and native rat serotonin 5-HT1A receptors: affinity, efficacy and potential implications for treatm... Int J Neuropsychopharmacol. 2005 Sep;8(3):341-56. | ||||
| REF 2 | End of the line for cannabinoid receptor 1 as an anti-obesity target An opinion. Nat Rev Drug Discov. 2009 Jul;8(7):594. | ||||
| REF 3 | Inhibition by tetanus toxin of sodium-dependent, high-affinity [3H]5-hydroxytryptamine uptake in rat synaptosomes. Biochem Pharmacol. 1999 Jan 1;57(1):111-20. | ||||
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