Target Validation Information
TTD ID	T87166
Target Name	Glucokinase (GCK)
Type of Target	Clinical trial
Action against Disease Model	Lonidamine	Drug Info	Lonidamine is an anticancer drug that has its primary action on cellular metabolism rather than cell division. Since lonidamine is not effective in all t uMor cells, we have tested it in two h uMan-t uMor cell culture lines: MOLT-4, a T-leukemia and U-87 MG, a glioma. Lonidamine exposure of MOLT-4 cells at 50 micrograms/mL and pH 6.7 disrupted the mitochondria within 1 h of treatment. The mitochondria were swollen and the cristae were disrupted. When the treated cells were re-incubated in fresh medi uM at pH 7.4 the mitochondria rapidly returned to their normal morphology.	[1]
References
REF 1	Morphological effects of lonidamine on two human-tumor cell culture lines. Scanning Microsc. 1989 Jun;3(2):681-91; discussion 691-3.

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