Target Validation Information
TTD ID	T98062
Target Name	Glycogen phosphorylase muscle form (GP)
Type of Target	Patented-recorded
Drug Potency against Target	PSN357	Drug Info	IC50 = 0.14 nM
	1-D-glucopyranosyl cytosine	Drug Info	Ki = 7700 nM	[4]
	1-D-glucopyranosyl uracil	Drug Info	Ki = 6100 nM	[4]
	2-Hydroxyiminoolean-12-en-28-oic acid	Drug Info	IC50 = 13100 nM	[3]
	2-Hydroxyiminours-12-en-28-oic acid	Drug Info	IC50 = 14700 nM	[3]
	2-isooleanolic acid	Drug Info	IC50 = 3500 nM	[3]
	2-isoursolic acid	Drug Info	IC50 = 5500 nM	[3]
	2-Oxoolean-12-en-28-oic acid	Drug Info	IC50 = 14900 nM	[3]
	23-hydroxybetulinic acid	Drug Info	IC50 = 16000 nM	[1]
	2alpha-Hydroxyolean-12-en-28-oic acid	Drug Info	IC50 = 8500 nM	[3]
	2alpha-Hydroxyurs-12-en-28-oic acid	Drug Info	IC50 = 1200 nM	[3]
	2beta,3alpha-dihydroxyolean-12-en-28-oic acid	Drug Info	IC50 = 6250 nM	[2]
	2beta,3alpha-dihydroxyurs-12-en-28-oic acid	Drug Info	IC50 = 1100 nM	[2]
	3alpha-Hydroxyurs-12-en-28-oic Acid	Drug Info	IC50 = 19000 nM	[1]
	ASIATIC ACID	Drug Info	IC50 = 17000 nM	[1]
	Benzyl 2-hydroxyiminoolean-12-en-28-oate	Drug Info	IC50 = 16300 nM	[3]
	BETULIN	Drug Info	IC50 = 17000 nM	[1]
	Ethyl 2beta-hydroxyolean-12-en-28-oate	Drug Info	IC50 = 15300 nM	[3]
	N-Butyl 2beta-hydroxyolean-12-en-28-oate	Drug Info	IC50 = 13800 nM	[3]
	OLEANOLIC_ACID	Drug Info	IC50 = 14000 nM	[1]
	Oleanonic acid	Drug Info	IC50 = 18000 nM	[1]
	URSOLIC ACID	Drug Info	IC50 = 15300 nM	[3]
Action against Disease Model	PSN357	Drug Info	Preclinical data also suggest a role for glycogen phosphorylase, as exemplified by the results obtained with GPI-688, PSN-357 and CP-368296 in animal models
References
REF 1	Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.
REF 2	Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. J Nat Prod. 2008 Nov;71(11):1877-80.
REF 3	Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
REF 4	1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modellin... Bioorg Med Chem. 2010 May 15;18(10):3413-25.

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