Target Information
| Target General Information | Top | |||||
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| Target ID |
T32282
(Former ID: TTDR00418)
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| Target Name |
Prolactin (PRL)
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| Synonyms |
GHA1
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| Gene Name |
PRL
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| Target Type |
Discontinued target
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[1] | ||||
| Disease | [+] 1 Target-related Diseases | + | ||||
| 1 | Multiple sclerosis [ICD-11: 8A40] | |||||
| Function |
Prolactin acts primarily on the mammary gland by promoting lactation.
Click to Show/Hide
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| BioChemical Class |
Somatotropin/prolactin
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| UniProt ID | ||||||
| Sequence |
MNIKGSPWKGSLLLLLVSNLLLCQSVAPLPICPGGAARCQVTLRDLFDRAVVLSHYIHNL
SSEMFSEFDKRYTHGRGFITKAINSCHTSSLATPEDKEQAQQMNQKDFLSLIVSILRSWN EPLYHLVTEVRGMQEAPEAILSKAVEIEEQTKRLLEGMELIVSQVHPETKENEIYPVWSG LPSLQMADEESRLSAYYNLLHCLRRDSHKIDNYLKLLKCRIIHNNNC Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| HIT2.0 ID | T86YQL | |||||
| Drugs and Modes of Action | Top | |||||
|---|---|---|---|---|---|---|
| Discontinued Drug(s) | [+] 1 Discontinued Drugs | + | ||||
| 1 | NTx-488 | Drug Info | Discontinued in Phase 2 | Multiple sclerosis | [2] | |
| Mode of Action | [+] 1 Modes of Action | + | ||||
| Modulator | [+] 1 Modulator drugs | + | ||||
| 1 | NTx-488 | Drug Info | [1] | |||
| Target Regulators | Top | |||||
|---|---|---|---|---|---|---|
| Target-regulating Transcription Factors | ||||||
| Target Profiles in Patients | Top | |||||
|---|---|---|---|---|---|---|
| Target Expression Profile (TEP) | ||||||
| Target Affiliated Biological Pathways | Top | |||||
|---|---|---|---|---|---|---|
| KEGG Pathway | [+] 5 KEGG Pathways | + | ||||
| 1 | Cytokine-cytokine receptor interaction | |||||
| 2 | Neuroactive ligand-receptor interaction | |||||
| 3 | PI3K-Akt signaling pathway | |||||
| 4 | Jak-STAT signaling pathway | |||||
| 5 | Prolactin signaling pathway | |||||
| NetPath Pathway | [+] 1 NetPath Pathways | + | ||||
| 1 | IL2 Signaling Pathway | |||||
| PID Pathway | [+] 4 PID Pathways | + | ||||
| 1 | ErbB4 signaling events | |||||
| 2 | Signaling events mediated by PTP1B | |||||
| 3 | Glucocorticoid receptor regulatory network | |||||
| 4 | Validated nuclear estrogen receptor alpha network | |||||
| Reactome | [+] 3 Reactome Pathways | + | ||||
| 1 | Prolactin receptor signaling | |||||
| 2 | Amyloid formation | |||||
| 3 | Growth hormone receptor signaling | |||||
| WikiPathways | [+] 5 WikiPathways | + | ||||
| 1 | Prostaglandin Synthesis and Regulation | |||||
| 2 | EV release from cardiac cells and their functional effects | |||||
| 3 | Prolactin receptor signaling | |||||
| 4 | Growth hormone receptor signaling | |||||
| 5 | JAK/STAT | |||||
| References | Top | |||||
|---|---|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028330) | |||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028330) | |||||
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