Target Information

Content Navigation (  All   None )                                      
Target General Information
Drug Binding Sites of Target
Different Human System Profiles of Target
Chemical Structure based Activity Landscape of Target
Drug Property Profile of Target
Target Poor or Non Binders
Target Regulators
References
Drug Binding Sites of Target  Top
Ligand Name: N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid Ligand Info
Structure Description Crystal structure of the catalytic domain of human matrix metalloproteinase 10 PDB:1Q3A
Method X-ray diffraction Resolution 2.10 Å Mutation Yes [3]
PDB Sequence
MPKWRKTHLT
114
YRIVNYTPDL
124
PRDAVDSAIE
134
KALKVWEEVT
144
PLTFSRLYEG
154

EADIMISFAV
164
KEHGDNYSFD
174
GPGHSLAHAY
184
PPGPGLYGDI
194
HFDDDEKWTE
204

DASGTNLFLV
214
AAHELGHSLG
224
LFHSANTEAL
234
MYPLYNSLAQ
247
FRLSQDDVNG
257

IQSLYG
Residue
Distance (Å)
HIS178
3.492
SER179
3.042
LEU180
2.172
ALA181
2.567
HIS182
4.003
LEU213
3.661
VAL214
3.720
HIS217
3.101
GLU218
2.407
Residue
Distance (Å)
HIS221
3.568
HIS227
3.003
LEU234
3.920
TYR236
4.243
PRO237
3.180
LEU238
4.013
TYR239
4.105
SER241
2.965
Click to View More Binding Site Information of This Target with Different Ligands
Different Human System Profiles of Target  Top
Human Similarity Proteins of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs (Brief Bioinform, 21: 649-662, 2020).
Human Tissue Distribution of target is determined from a proteomics study that quantified more than 12,000 genes across 32 normal human tissues. Tissue Specificity (TS) score was used to define the enrichment of target across tissues.
The distribution of targets among different tissues or organs need to be taken into consideration when assessing the target druggability, as it is generally accepted that the wider the target distribution, the greater the concern over potential adverse effects (Nat Rev Drug Discov, 20: 64-81, 2021).
Biological Network Descriptors of target is determined based on a human protein-protein interactions (PPI) network consisting of 9,309 proteins and 52,713 PPIs, which were with a high confidence score of ≥ 0.95 collected from STRING database.
The network properties of targets based on protein-protein interactions (PPIs) have been widely adopted for the assessment of target’s druggability. Proteins with high node degree tend to have a high impact on network function through multiple interactions, while proteins with high betweenness centrality are regarded to be central for communication in interaction networks and regulate the flow of signaling information (Front Pharmacol, 9, 1245, 2018; Curr Opin Struct Biol. 44:134-142, 2017).
Human Similarity Proteins
Human Tissue Distribution
Biological Network Descriptors
There is no similarity protein (E value < 0.005) for this target
Note: If a protein has TS (tissue specficity) scores at least in one tissue >= 2.5, this protein is called tissue-enriched (including tissue-enriched-but-not-specific and tissue-specific). In the plots, the vertical lines are at thresholds 2.5 and 4.
Degree 4 Degree centrality 4.30E-04 Betweenness centrality 1.02E-05
Closeness centrality 1.97E-01 Radiality 1.34E+01 Clustering coefficient 3.33E-01
Neighborhood connectivity 1.98E+01 Topological coefficient 3.31E-01 Eccentricity 13
Download Click to Download the Full PPI Network of This Target

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.