Target Information
Target General Information | Top | |||||
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Target ID |
T42748
(Former ID: TTDI01832)
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Target Name |
Serotoninnorepinephrinedopamine reuptake (SNDR)
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Gene Name |
NO-GeName
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Target Type |
Successful target
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[1] | ||||
Disease | [+] 2 Target-related Diseases | + | ||||
1 | Attention deficit hyperactivity disorder [ICD-11: 6A05] | |||||
2 | Depression [ICD-11: 6A70-6A7Z] | |||||
UniProt ID |
Drugs and Modes of Action | Top | |||||
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Approved Drug(s) | [+] 2 Approved Drugs | + | ||||
1 | Dasotraline | Drug Info | Approved | Attention deficit hyperactivity disorder | [2] | |
2 | Olanzapine/fluoxetine combination | Drug Info | Approved | Depression | [1] | |
Clinical Trial Drug(s) | [+] 3 Clinical Trial Drugs | + | ||||
1 | OPC-64005 | Drug Info | Phase 2 | Attention deficit hyperactivity disorder | [3] | |
2 | RP5063 | Drug Info | Phase 2 | Schizophrenia | [4] | |
3 | Brilaroxazine | Drug Info | Phase 1 | Idiopathic pulmonary fibrosis | [5] | |
Mode of Action | [+] 4 Modes of Action | + | ||||
Inhibitor | [+] 2 Inhibitor drugs | + | ||||
1 | Dasotraline | Drug Info | [2] | |||
2 | OPC-64005 | Drug Info | [6] | |||
Antagonist | [+] 1 Antagonist drugs | + | ||||
1 | Olanzapine/fluoxetine combination | Drug Info | [1] | |||
Partial agonist | [+] 1 Partial agonist drugs | + | ||||
1 | RP5063 | Drug Info | [2] | |||
Agonist | [+] 1 Agonist drugs | + | ||||
1 | Brilaroxazine | Drug Info | [5] |
References | Top | |||||
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REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||||
REF 3 | ClinicalTrials.gov (NCT03324581) The Safety and Efficacy of OPC-64005 in the Treatment of Adult Attention-deficit/Hyperactivity Disorder. U.S. National Institutes of Health. | |||||
REF 4 | ClinicalTrials.gov (NCT01490086) RP5063 in Subjects With Schizophrenia or Schizoaffective Disorder. U.S. National Institutes of Health. | |||||
REF 5 | Clinical pipeline report, company report or official report of Reviva Pharmaceuticals | |||||
REF 6 | Clinical pipeline report, company report or official report of Otsuka Pharmaceutical. |
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