Resistance mutation info of target
| Target General Information | ||||||||||||||||||
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| Target ID | T05152 | |||||||||||||||||
| Target Name | HCV RNA-directed RNA polymerase (NS5B) | |||||||||||||||||
| Gene Name | NS5B | |||||||||||||||||
| Species | Hepatitis C virus genotype 1b | |||||||||||||||||
| UniProt ID | POLG_HCVJA(2420-3010) | |||||||||||||||||
| Sequence |
SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVL DDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIR SVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS TLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIY QCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLW ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG EINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIP AASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR [Hepatit is C virus genotype 1b] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: F415Y | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: S282T | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-nae patients. Hepatology. 2008 Dec;48(6):1769-78. | |||||||||||||||||
| REF 2 | Lam, A.M. et al. Selection and characterization of heaptitis C virus replicons using combinations of NS3 protease and NS5B non-nucleoside inhibitors or combination of NS5B nucleotide inhibitors. . in International HIV & Hepatitis Virus Drug Resistance Workshop, Vol. 15 Supplement 2 A28 (Dubrovnik, Croatia, 2010). | |||||||||||||||||
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