Target General Information
Target ID	T09826
Target Name	Toposisomerase-1 (TOP1)
Gene Name	TOP1
Species	Homo sapiens
UniProt ID	TOP1_HUMAN
Sequence	MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info	Missense: E710G
Drugs	Drug Name Irinotecan Drug Info [1] Targeted Disease Colorectal cancer
	Drug Name Camptothecin Drug Info [1] Targeted Disease Colorectal cancer
Mutation Info	Missense: L617H
Drugs	Drug Name Irinotecan Drug Info [1] Targeted Disease Colorectal cancer
	Drug Name Camptothecin Drug Info [1] Targeted Disease Colorectal cancer
Mutation Info	Missense: R621I
Drugs	Drug Name Irinotecan Drug Info [1] Targeted Disease Colorectal cancer
	Drug Name Camptothecin Drug Info [1] Targeted Disease Colorectal cancer
Mutation Info	Missense: R634A
Drugs	Drug Name Camptothecin Drug Info [2] Targeted Disease Colorectal cancer
References
REF 1	New Topoisomerase I mutations are associated with resistance to camptothecin.Mol Cancer.2011 May 27;10:64.
REF 2	The human topoisomerase 1B Arg634Ala mutation results in camptothecin resistance and loss of inter-domain motion correlation.Biochim Biophys Acta.2013 Dec;1834(12):2712-21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.