Target General Information
Target ID T13491
Target Name Equilibrative nucleoside transporter 1 (SLC29A1)
Gene Name SLC29A1
Species Homo sapiens
UniProt ID S29A1_HUMAN
Sequence MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDA
QASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAIL
LVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQ
GLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKL
EGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIF
TITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRW
LPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPK
KVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV [Homo sapiens]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: G24R
Drugs
Drug Name Cytarabine (Ara-C) Drug Info [1]
Targeted Disease T cell leukemia
References
REF 1 Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells.FEBS Lett.2009 Jan 22;583(2):425-9.

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