Resistance mutation info of target
| Target General Information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T13852 | |||||||||||||||||
| Target Name | Sphingosine 1-phosphate receptor 1 (S1PR1) | |||||||||||||||||
| Gene Name | S1PR1 | |||||||||||||||||
| Species | Homo sapiens | |||||||||||||||||
| UniProt ID | S1PR1_HUMAN | |||||||||||||||||
| Sequence |
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH PQKDEGDNPETIMSSGNVNSSS [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | ||||||||||||||||||
| Mutation Info | Missense: G305C | |||||||||||||||||
| Drugs |
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| Mutation Info | Missense: I45T | |||||||||||||||||
| Drugs |
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| References | ||||||||||||||||||
| REF 1 | Individual variation of human S1P coding sequence leads to heterogeneity in receptor function and drug interactions.J Lipid Res.2014 Dec;55(12):2665-75. | |||||||||||||||||
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