| Target General Information |
| Target ID |
T95678
|
| Target Name |
Influenza Proton channel protein (M2) |
| Gene Name |
M2 |
| Species |
Influenza A viruses H1N1 |
| UniProt ID |
M2_I35A3 |
| Sequence |
MSLLTEVETPIRNEWGCRCNGSSDPLVIAASIIGILHLILWILDRLLFKCIYRRFKYGLK
RGPSTEGVPESMREEYRKEQQSAVDADDGHFVNIEPE [Influenza A viruses H
1N1]
|
| Drug and Corresponding Resistance Mutations |
| Mutation Info |
Missense: S31N |
| Drugs |
| Drug Name |
Oseltamivir |
Drug Info
|
[1] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Amantadine |
Drug Info
|
[1], [2] |
| Targeted Disease |
Influenza virus infection |
|
| Drug Name |
Memantine |
Drug Info
|
[3] |
| Targeted Disease |
Influenza virus infection |
|
| References |
| REF 1 |
Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76.
|
| REF 2 |
Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.BMC Genet.2015;16 Suppl 2:S3.
|
| REF 3 |
Discovery of Potential, Non-Toxic Influenza Virus Inhibitor by Computational Techniques. Mol Inform. 2014 Aug;33(8):559-65.
|
