Drug Information

Drug General Information
Drug ID
D06FDR
Former ID
DAP000702
Drug Name
Didanosine
Synonyms
DDI; DIDEOXYINOSINE; DdIno; Didanosina; Didanosinum; Videx; Hypoxanthine ddN; Videx EC; BMY 40900; BMY-40900; DRG-0016; DdI + d4T combination; Didanosina [INN-Spanish]; Didanosinum [INN-Latin]; Dideoxyinosine (DDI); Intron A & Videx; KS-1049; LOA & ddI; Videx (TN); Videx EC (TN); Videx(TM); DDI and rIFN.alpha.2; DS-4152 & ddI; DdI & GM-CSF; DdI & IFN-alpha; DdI & sCD4(rsCD4); PC-SOD+ddI; Didanosine (JAN/USAN/INN); Videx EC(TM)(slow-release capsules); Didanosine and Interferon-.alpha.-2; Listera ovata agglutinin & 2',3'-Dideoxyinosine; Sulfated polysaccharide-peptidoglycan DS-4152 & 2',3'-Dideoxyinosine; Inosine, 2',3'-dideoxy-& Recombinant Interferon-.alpha.-2; 2',3'-Dideoxyinosine; 2',3'-Dideoxyinosine & Granulocyte-macrophage colony-stimulating factor; 2',3'-Dideoxyinosine & Interferon-alpha; 2',3'-Dideoxyinosine & sCD4(soluble recombinant protein); 2',3'-Dideoxyinosine (AIDS Initiative); 2',3'-Dideoxyinosine (ddI); 2',3'-dideoxyinosine, DDI, NSC 612049, Didanosine; 2'3'-DIDEOXYINOSINE; 2,3-dideoxyinosine; 3'-Azido-3'-deoxythymidine + 2',3'-Dideoxyinosine; 9-((2R,5S)-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 9-((2R,5S)-5-Hydroxymethyl-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)-6-oxopurine; 9-(2,3-Dideoxy-beta-D-ribofuranosyl)hypoxanthine; 9-[(2R,5R)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL]-1,9-DIHYDRO-6H-PURIN-6-ONE; 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one; 9-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one; DDI
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Approved [468066], [536361]
Therapeutic Class
Anti-HIV Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C10H12N4O3
InChI
InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1
InChIKey
BXZVVICBKDXVGW-NKWVEPMBSA-N
CAS Number
CAS 69655-05-6
PubChem Compound ID
50599
PubChem Substance ID
9168, 595889, 596438, 596681, 597344, 601538, 602978, 622273, 833736, 7847362, 7885163, 7979070, 7979071, 12014245, 14847321, 15121787, 15121788, 15196316, 17389541, 22431600, 25819905, 26719672, 26754510, 26757698, 29215491, 34715128, 46386730, 46506255, 46508438, 48415887, 48422196, 48422428, 48423223, 48424479, 49681777, 49718183, 56463354, 57313303, 58717761, 77794640, 81093234, 87351572, 87559876, 90451743, 91612512, 92308421, 92308956, 92711314, 92729668, 103529091
SuperDrug ATC ID
J05AF02
SuperDrug CAS ID
cas=069655056
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [537278]
References
Ref 468066(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4833).
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537278The effect of individual antiretroviral drugs on body composition in HIV-infected persons initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2009 Jul 1;51(3):298-304.

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