Drug General Information
Drug ID
DX3WDD
Drug Name
1-(biphenyl-4-yl)-3-(4-(2-methoxyphenyl)piperazin-1-yl)propan-1-ol
Synonyms
CHEMBL135824
Indication Discovery agent Investigative [1587926]
Formula
C26H30N2O2
Canonical SMILES
COc1ccccc1N2CCN(CCC(O)c3ccc(cc3)c4ccccc4)CC2
InChI
InChI=1S/C26H30N2O2/c1-30-26-10-6-5-9-24(26)28-19-17-27(18-20-28)16-15-25(29)23-13-11-22(12-14-23)21-7-3-2-4-8-21/h2-14,25,29H,15-20H2,1H3
InChIKey
LLNFVVXSTGRSIR-UHFFFAOYSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info [1587926]
Sodium-dependent serotonin transporter Target Info [1587926]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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